Expression of human epithelial growth factor receptor 2 in advanced lung adenocarcinoma with epithelial growth factor receptor mutation and its significance / 肿瘤研究与临床

Objective To detect the expression of human epithelial growth factor receptor 2 (HER-2) in advanced lung adenocarcinoma with epithelial growth factor receptor (EGFR) mutation, and to explore the potential of HER-2 as a therapeutic target for drug resistance in patients with EGFR mutations. Methods HER-2 is commonly expressed in the advanced lung adenocarcinoma with EGFR mutations, mainly in the cell membrane. Results The overexpression rate of HER-2 protein in tissues of advanced lung adenocarcinoma with EGFR mutations was 33.3%(28/84). The overexpression rate of HER-2 protein in patients>50 years of age was 40.3%(27/67), which was significantly higher than that of patients ≤50 years of age [5.9 % (1/17)], the difference was statistically significant (χ2=7.227, P=0.007). The overexpression rate of HER-2 protein in patients with high pathological differentiation [44.4 % (8/18)] was higher than that in patients with poor pathological differentiation [30.3%(20/66)], but the difference was not statistically significant (χ2=1.273, P=0.259). The overexpression of HER-2 protein in patients with EGFR 21 exon mutation [40.5 % (17/42)] was significantly higher than that of EGFR19 exon mutation [25.0%(10/40)], but the difference was not statistical significance (χ2=2.222, P=0.136). Conclusions The overexpression rate of HER-2 protein in advanced lung adenocarcinoma patients with EGFR mutation is high, which is related to the age and tumor differentiation. HER-2 is expected to be a potential therapeutic target for drug resistance patients with EGFR mutations.

Progress in association of RSK2 with malignancies and its inhibitors / 中国病理生理杂志

RibosomalS6kinase2(RSK2)isamemberofthep90Rsk,whichbelongstoSer/Thrkinasefami-ly.It is a downstream molecule of Ras/MAPK cascade and regulates a variety of cellular processes.RSK2 plays a key role in the cell proliferation, survival and transformation.Furthermore, the aberrant up-regulation of RSK2 was observed in dif-ferent malignancies.We here briefly review the structure and function of RSK2, the relationship between RSK2 and tumor, and the existing RSK2 inhibitors.